Hormonal
Calorie restriction-induced weight loss does not restore or alter the secretion of appetite-inhibiting gut hormones (GLP-1, PYY, CCK, GIP, NT, SST) or their gene expression in the small intestine of obese subjects.
If you have lost weight, do not expect your hunger hormones to normalize. Your body may still signal hunger as strongly as it did when you were heavier. This biological persistence is a key reason for weight regain, so you must rely on external strategies (dietary structure, behavioral habits) to manage appetite, as your internal hormonal signals will not naturally support maintenance.
These data suggest that the attenuated postprandial responses of GLP- 1, as well as reduced responses of other appetite- inhibiting gut hormones, in people living with obesity may persist after weight loss and may contribute to their susceptibility for weight regain.
Why this rating
High-quality mechanistic data in a controlled animal model (perfused rat intestine), but extrapolation to humans is speculative.
Source
Weight loss by calorie restriction does not alter appetite‐regulating gut hormone responses from perfused rat small intestine
Marina Kjærgaard Gerstenberg et al. · Acta Physiologica · 2023
DOI 10.1111/apha.13947
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →