Research
Hormonal
Myostatin and activin A inhibitors (e.g., bimagrumab, trevogrumab, garetosmab) combined with GLP-1 agonists can increase lean mass and reduce fat mass more effectively than GLP-1 agonists alone.
New drugs targeting myostatin (like bimagrumab) are being tested alongside GLP-1s to build muscle while losing fat. These are currently in clinical trials and not yet widely available.
ModerateSupportsMEDIUM confidence
Preliminary findings suggest a possible muscle gain of 6%-8% through the co-blockade of activin and myostatin.
Why this rating
Based on phase 2 trials and preliminary findings; not yet large-scale phase 3 results.
Source
Saving muscle while losing weight: A vital strategy for sustainable results while on glucagon-like peptide-1 related drugs
Maja Cigrovski Berković et al. · World Journal of Diabetes · 2025
DOI 10.4239/wjd.v16.i9.109123
narrative_reviewCited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- GLP-1 receptor agonists (semaglutide, tirzepatide, retatrutide) cause significant loss of lean muscle mass (up to 40% of total weight loss), which contributes to reduced resting energy expenditure and increased risk of sarcopenia and weight regain.Good
- Combining GLP-1 receptor agonists with resistance training and/or specific nutritional strategies (e.g., higher protein, ketogenic therapy) preserves fat-free mass and muscle strength better than pharmacotherapy alone.Good
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