Hormonal
Liraglutide 3.0 mg, a GLP-1 analogue, promotes weight loss and improves metabolic parameters through mechanisms involving hypothalamic energy balance regulation, glucose-dependent insulin stimulation, and slowed gastric emptying.
Liraglutide 3.0 mg works by mimicking a natural hormone that regulates hunger, insulin, and digestion. It is taken as a daily injection, starting at a low dose and increasing weekly to reduce side effects like nausea. It is contraindicated for those with specific thyroid cancer histories.
Liraglutide acts on hypothalamic neurons involved in energy balance and centers linked to pleasure and reward, stimulates pancreatic glucose-dependent insulin production, inhibits glucagon and somatostatin, and slows gastric emptying
Why this rating
Well-established pharmacological mechanism described in the position statement.
Source
Pharmacologic Treatment of Obesity in adults and its impact on comorbidities: 2024 Update and Position Statement of Specialists from the Brazilian Association for the Study of Obesity and Metabolic Syndrome (Abeso) and the Brazilian Society of Endocrinology and Metabolism (SBEM)
Rodrigo O. Moreira et al. · Archives of Endocrinology and Metabolism · 2024
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