Hormonal
Anti-obesity medications (AOMs), particularly semaglutide, produce statistically significant weight reduction in older adults (≥65 years), with the strongest evidence supporting their use in those with established cardiovascular disease.
If you are 65 or older and have obesity, anti-obesity medications like semaglutide can help you lose weight, especially if you have heart disease. The weight loss is significant (around 7-8% in major trials), but you may experience more side effects like nausea or dizziness. Work with your doctor to start slowly and monitor your health.
All studies found statistically significant weight reduction between intervention and placebo group or compared to baseline weight... Limited evidence suggests weight reduction of AOMs in older adults, with the best current evidence for the use of semaglutide in older adults with obesity and cardiovascular disease.
Why this rating
Based on a systematic review of 8 studies (6 experimental, 2 observational), but limited by small sample sizes of older adults, high risk of bias in some trials, and lack of long-term data.
Source
Efficacy of antiobesity medications for weight reduction in older adults: a systematic review
Alissa S. Chen et al. · Obesity · 2024
DOI 10.1002/oby.24160
Related findings · Hormonal
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- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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