Research
Hormonal
Bariatric surgery (specifically Sleeve Gastrectomy and Roux-en-Y Gastric Bypass) alters gut peptide profiles by increasing postprandial PYY and decreasing postprandial total and acylated ghrelin, which correlates with reduced hunger and increased fullness, whereas low-calorie diet does not produce these favorable gut peptide changes.
Bariatric surgery changes your gut hormones to help you feel fuller faster and less hungry, which supports weight loss. This hormonal change is not seen with dieting alone. You may need to adjust your eating habits to accommodate these changes, such as eating smaller meals and chewing thoroughly.
GoodSupportsHIGH confidence
Postprandial total PYY increased more following BS while total and acylated ghrelin decreased more following BS compared to LCD. Hunger decreased and fullness increased with BS compared to LCD (p = .037; p = .010, respectively).
Why this rating
Same study limitations as N1 (small sample, observational), but gut peptide measurements are robust.
Source
Changes in insulin sensitivity and gut peptides 8 and 52 weeks after bariatric surgery or low‐calorie diet
Adam C. Lowe et al. · Clinical Obesity · 2024
DOI 10.1111/cob.12726
cohort · n=19Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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