Adherence
Among patients with severe obesity treated with semaglutide 2.4 mg/week, those with higher intuitive eating scores and lower anxiety/depression levels (Intuitive Eaters Group) achieve significantly greater weight loss than those with higher emotional distress and lower intuitive eating scores (Emotionally Driven Eaters Group).
If you are taking semaglutide for severe obesity, your mental health and eating mindset matter for your results. Patients with high emotional distress and lower intuitive eating skills tend to lose less weight than those with better emotional regulation and intuitive eating habits. To maximize your weight loss, consider integrating psychological support or intuitive eating strategies alongside your medication, as these factors significantly influence your trajectory.
In Phase 3, the IEG demonstrated a significantly more favorable weight-loss trajectory compared to the EDEG (p = 0.03)... At 12 months, the IEG lost 15.9% (6.8%), compared to 13.5% (5.7%) for the EDEG (p = 0.08)... a significantly higher proportion of IEG participants reached or exceeded the weight-loss thresholds of 10% and 15% reductions compared to the EDEG (p < 0.001)
Why this rating
Observational study with a relatively small Phase 3 cohort (n=125) and potential selection bias, but robust clustering validation in larger Phases 1 and 2.
Source
Clustering of intuitive eating and psychological health identifies subgroups associated with weight loss following semaglutide
A. Avignon et al. · Obesity · 2025
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