Research
Adherence
GLP-1 RAs are associated with an increased risk of suicidal behavior and self-harm, particularly in patients with underlying mental health vulnerabilities or dysphoria.
If you are taking Semaglutide and experience mood changes, depression, or suicidal thoughts, contact your healthcare provider immediately. Do not ignore these symptoms. Regular screening for mental health is recommended for all patients on this medication.
LimitedQualifiesLOW confidence
A possible link between GLP-1 RAs and suicidal behavior has been proposed... growing numbers of studies have found an association between GLP-1 RAs and possible self-injury thoughts... the current case report may serve as evidence of GLP-1 RAs overdose that raises suspicions regarding self-overdosing this medication in attempting suicide.
Why this rating
Based on a single case report and references to other studies/reports, not a large-scale controlled trial.
Source
Semaglutide Overdose in a Diabetic Patient: Suicidal Behavior and Multiorgan Failure
Doron Zamir et al. · American Journal of Case Reports · 2025
DOI 10.12659/ajcr.947682
case_report · n=1Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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