Adherence
Treatment with the Epitomee shape-shifting hydrogel capsule combined with lifestyle intervention significantly improves health-related quality of life (HRQOL), specifically in Physical Function and total scores, compared to placebo in adults with overweight or obesity.
If you are overweight or have obesity (BMI 27-40) and struggle with portion control, this hydrogel capsule may help improve your quality of life and physical function more than lifestyle changes alone. You take one capsule with a large glass of water 30 minutes before your two main meals daily. It expands in your stomach to help you feel full sooner. This approach is particularly useful if you want to avoid medications or have contraindications to them. The benefits are most pronounced if you lose 10% or more of your body weight, but even modest loss improves physical function scores significantly.
Compared to the placebo group, the Epitomee group consistently showed improved outcomes in total IWQOL-Lite-CT score and Physical Function sub-score (p < 0.05)... The Epitomee capsule, with lifestyle intervention, is associated with IWQOL-Lite-CT improvement, highlighting its potential as an effective non-pharmaceutical adjunct to lifestyle intervention for enhancing health outcomes in individuals with overweight and obesity.
Why this rating
Double-blind, placebo-controlled randomized trial with a moderate sample size (n=279) and high retention rate (86%), though limited to 24 weeks.
Source
Quality of life improvements associated with weight loss using a novel shape-shifting hydrogel capsule: RESET study results
Robert F. Kushner et al. · International Journal of Obesity · 2025
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