Hormonal
In drug-naive individuals with early type 2 diabetes, sitagliptin treatment (100 mg daily) reduces postprandial glucose excursions regardless of whether the meal is carbohydrate-rich, protein-rich, or lipid-rich.
If you have early type 2 diabetes and take sitagliptin, your blood sugar response to meals is improved regardless of whether you eat carbs, protein, or fat. While protein and fat-rich meals naturally cause smaller blood sugar spikes, the medication helps manage glucose levels across all meal types. This makes dietary flexibility easier, as you don't need to strictly avoid carbohydrates to benefit from the drug's glucose-lowering effects.
Sitagliptin treatment reduced but did not normalize fasting and post-meal glucose values in the three MTTs, with lowered area-under-glucose-curve values varying from 7% to 15%. ... The blood glucose excursion during meal ingestion is minimal in protein- or fat-rich meals, which can be a positive ally for the management of T2DM.
Why this rating
Randomized, double-blind, placebo-controlled crossover design with a small sample size (n=16).
Source
The effects of macronutrients composition on hormones and substrates during a meal tolerance test in drug-naive and sitagliptin-treated individuals with type 2 diabetes: a randomized crossover study
Cristina da Silva Schreiber et al. · Archives of Endocrinology and Metabolism · 2022
DOI 10.20945/2359-3997000000478
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