Hormonal
Depression is uniquely and significantly associated with increased GLP-1RA utilization in women, suggesting a complex interplay between mental health comorbidities and medication access.
For women, having a diagnosis of depression is linked to a higher likelihood of being prescribed GLP-1RAs. This may reflect targeted prescribing or the complex relationship between mental health and weight management. It highlights the need for sex-sensitive screening and holistic care that addresses both metabolic and psychiatric health.
Among women, depression was linked to greater use... Depression was also associated with increased use in women (Table 2).
Why this rating
Statistically significant association found in multivariable logistic regression, though causality is limited by cross-sectional design.
Source
Beyond glycemic control: Sex differences shaping glucagon-like peptide-1 receptor agonist utilization in the United States
Samuel Chijioke Ofili et al. · Journal of Managed Care & Specialty Pharmacy · 2026
DOI 10.18553/jmcp.2026.32.2.166
More from this paper
- GLP-1 receptor agonist utilization for obesity has increased significantly and disproportionately among women compared to men, with obesity emerging as a key predictor of use specifically in female patients.Good
- In patients with Type 2 Diabetes, GLP-1RA use is strongly associated with prior use of insulin and multiple oral antidiabetic agents, indicating their role as intensification therapies for poorly controlled diabetes.Good
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