Research
Adherence
Mandibular advancement devices (MADs) provide symptom relief comparable to CPAP in mild-to-moderate OSA primarily due to superior long-term adherence, despite CPAP's superior objective efficacy in reducing AHI.
If you have mild-to-moderate sleep apnea and struggle with CPAP, ask about a mandibular advancement device. It might not reduce your apnea events as much as CPAP, but you are more likely to use it every night, which often leads to better overall health outcomes and symptom relief.
GoodQualifiesHIGH confidence
Mandibular advancement devices (MADs) consistently reduced AHI relative to placebo and produced symptom relief comparable to CPAP in mild-to-moderate OSA, largely due to superior adherence.
Why this rating
Based on multiple RCTs and comparative cohorts cited in the review.
Source
Redefining Obstructive Sleep Apnea: Treatment in the Modern Era
Jose Redondo et al. · Pathophysiology · 2026
DOI 10.3390/pathophysiology33010020
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Maxillomandibular advancement (MMA) surgery achieves the largest and most durable reductions in OSA severity, with efficacy comparable to CPAP.Good
- GLP-1-based therapies, particularly dual GLP-1/GIP agonists like tirzepatide, produce large, clinically meaningful reductions in AHI and cardiometabolic risk in obesity-associated OSA.Good
- Hypoglossal nerve stimulation (HNS) produces substantial, durable improvements in AHI and symptoms with high adherence, supported by randomized trials and real-world data.Good
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