Research
Hormonal
Statins are the first-line pharmacologic therapy for lowering LDL-C and reducing cardiovascular events in patients with Type 2 Diabetes, regardless of baseline cholesterol levels.
If you have Type 2 Diabetes, talk to your doctor about starting a statin. It is the most effective way to lower your risk of heart attack and stroke, even if your cholesterol numbers look okay. Lifestyle changes are important, but statins provide the strongest protection.
StrongSupportsVERY_HIGH confidence
The HMG CoA reductase inhibitors, or 'statins,' are the most effective pharmacologic agents for reducing LDL-C concentrations and should be considered first-line therapy for this purpose, both in individuals with and without T2DM [48,63].
Why this rating
Supported by multiple large placebo-controlled clinical trials (CARDS, HPS, 4S, LIPID, etc.) and meta-analyses.
Source
Lipid and lipoprotein metabolism, hypolipidemic agents, and therapeutic goals
Gissette Reyes‐Soffer et al. · 2015
book_chapter
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