Research
Hormonal
SGLT2 inhibitors (empagliflozin, dapagliflozin) reduce cardiovascular death, heart failure hospitalizations, and renal composite outcomes in patients with type 2 diabetes and chronic kidney disease, regardless of baseline glycemic control.
If you have Type 2 Diabetes and heart or kidney issues, ask your doctor about SGLT2 inhibitors like empagliflozin or dapagliflozin. These medications are proven to significantly lower your risk of heart failure, kidney failure, and death, offering protection beyond just blood sugar control.
StrongSupportsVERY_HIGH confidence
The Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG)-OUTCOME trial... finding that empagliflozin reduced cardiovascular death by 38% and hospitalization for HF by 35% compared with placebo... In the Dapagliflozin And Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) trial... dapagliflozin reduced the composite of sustained eGFR decline, ESRD, or renal/cardiovascular death by 39%.
Why this rating
Based on large-scale randomized controlled trials (EMPA-REG, DAPA-CKD) with significant sample sizes.
Source
Cardio-Renal Metabolic Syndrome: An Integrated Approach to Prevention and Management
Adeshpal Singh et al. · Cureus · 2025
narrative_review
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