Hormonal
Intensive lifestyle interventions (ILIs) targeting fat reduction (specifically visceral and body fat mass) significantly improve complete remission rates in overweight patients undergoing fertility-sparing treatment for endometrial cancer and intraepithelial neoplasia.
For overweight patients undergoing fertility-sparing treatment for endometrial precancer, intensive lifestyle changes focusing on fat loss (not just scale weight) significantly improve remission rates. This involves a caloric deficit, daily moderate aerobic exercise, and resistance training to protect muscle mass. Aim for a modest ~3% weight loss, as excessive loss may reduce efficacy by depleting muscle.
ILIs-based weight management, particularly targeting fat reduction, is associated with enhanced FST efficacy in overweight EC/EIN patients.
Why this rating
Retrospective cohort study with propensity score matching, but not a randomized controlled trial.
Source
Fat reduction mediates the efficacy of intensive lifestyle interventions on fertility‐sparing treatment in overweight patients with endometrial cancer and intraepithelial neoplasia
Sijia Liu et al. · Acta Obstetricia Et Gynecologica Scandinavica · 2026
DOI 10.1111/aogs.70231
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