Research
Hormonal
Serum resistin levels are directly correlated with resistin mRNA expression in abdominal subcutaneous adipose tissue, suggesting adipose tissue is a source of circulating resistin.
Measuring resistin mRNA in fat biopsies is a valid proxy for estimating serum resistin levels in obese individuals, as they are strongly correlated.
GoodSupportsHIGH confidence
A strong correlation was observed between serum resistin and resistin mRNA expression from abdominal sc adipose tissue in a separate group of obese subjects (r = 0.62; P < 0.01; n = 56).
Why this rating
Strong statistical correlation (r=0.62, P<0.01) in a decent-sized subgroup (n=56).
Source
Relationship between Serum Resistin Concentrations and Insulin Resistance in Nonobese, Obese, and Obese Diabetic Subjects
Leonie K. Heilbronn et al. · The Journal of Clinical Endocrinology & Metabolism · 2004
DOI 10.1210/jc.2003-031410
cross_sectional · n=90Cited 307×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Serum resistin concentrations are not significantly correlated with insulin sensitivity (glucose disposal rate) in obese or obese diabetic humans, indicating resistin is unlikely to be a major mediator of insulin resistance in these populations.Good
- In nonobese humans, there is a weak inverse correlation between serum resistin and insulin sensitivity, but this association disappears when adjusting for body fat percentage.Good
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