Research

Hormonal

Obesity increases the risk of various cancers (e.g., breast, colorectal, liver) through mechanisms involving chronic inflammation, oxidative stress, and altered adipokine secretion (e.g., increased leptin, decreased adiponectin).

Obesity increases your risk for several types of cancer through biological processes like inflammation and hormone imbalance. Maintaining a healthy weight can reduce this risk by mitigating these specific biological factors.

StrongSupportsHIGH confidence
Obesity is known to be associated with 13 types of cancer... The association of obesity with cancer is biologically complex... Many studies have indicated that obesity-related effects on DNA damage and/or repair pathways may be involved... Increased free fatty acids (FFAs) in the serum of obese individuals promote the expression of vascular endothelial growth factor-A (VEGF-A)... resulting in insulin resistance and steatosis in the liver.
Xin Jin et al. · Acta Pharmaceutica Sinica B · 2023

Why this rating

Supported by multiple meta-analyses and mechanistic studies cited in the review.

Source

Pathophysiology of obesity and its associated diseases

Xin Jin et al. · Acta Pharmaceutica Sinica B · 2023

narrative_reviewCited 427×
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