Research
Hormonal
Calorie restriction reduces the production of Prostaglandin E2 (PGE2), a suppressive factor for T-cells, which contributes to enhanced immune function.
Reducing calories, especially by 30%, lowers PGE2, a compound that suppresses T-cells. This reduction helps your immune system work better.
GoodSupportsHIGH confidence
The decline in PGE2 production following CR in humans might partly contribute to the CR-induced enhancement of T-cell function as PGE2 has been shown to be a negative regulator of T cells.
Why this rating
Measured directly in the same RCT.
Source
Calorie Restriction Enhances T-Cell-Mediated Immune Response in Adult Overweight Men and Women
Tanvir Ahmed et al. · The Journals of Gerontology Series A · 2009
DOI 10.1093/gerona/glp101
rct · n=46Cited 73×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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