Hormonal
Elevated cholesteryl ester transfer protein (CETP) activity is significantly higher in South Asians compared to Europeans and drives the characteristic atherogenic dyslipidemia (high triglycerides, high LDL particle number, low HDL-C) observed in this population.
For South Asian individuals, standard cholesterol tests (LDL-C) may underestimate cardiovascular risk. It is critical to assess lipoprotein particle numbers (via NMR or ApoB) and CETP activity if available, as elevated CETP drives the formation of small, dense LDL particles and low HDL, which are strong predictors of heart disease in this population.
CETP activity was significantly greater by 30% in South Asians compared with Europeans... CETP activity was directly associated with serum triglycerides and inversely with HDL-C in the whole population. CETP activity was also directly related to apoB and LDL particle number.
Why this rating
The study uses a well-characterized, large cross-sectional cohort (N=482) with rigorous NMR spectroscopy for lipoprotein quantification, though it is observational and not interventional.
Source
Elevated cholesteryl ester transfer protein (CETP) activity, a major determinant of the atherogenic dyslipidemia, and atherosclerotic cardiovascular disease in South Asians
Shirya Rashid et al. · European Journal of Preventive Cardiology · 2014
DOI 10.1177/2047487314528461
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