Hormonal
Regular aerobic training reduces platelet activation (P-selectin expression) during acute exercise compared to sedentary individuals, despite higher baseline platelet counts in trained subjects.
If you are currently sedentary, your platelets will activate more during intense exercise than if you were trained. This doesn't mean you shouldn't exercise, but it highlights why gradual training is safer. Start with moderate activity to build your cardiovascular system, which will eventually lower your platelet activation response to stress.
platelet activation in trained was lower (P = 0.05) than sedentary (51 (cid:1) 6 vs. 59 (cid:1) 5%).
Why this rating
Randomized crossover design with healthy male subjects, though small sample size (n=16).
Source
The effect of exercise and training status on platelet activation: Do cocoa polyphenols play a role?
Indu Singh et al. · Platelets · 2006
DOI 10.1080/09537100600746953
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