Research
Hormonal
Chronic low-grade inflammation and oxidative stress in MASLD drive atrial structural and electrical remodeling, creating an arrhythmogenic substrate for AF.
Treating MASLD involves more than just liver health; it requires addressing systemic inflammation and oxidative stress to protect the heart from structural remodeling that leads to AF.
ModerateSupportsMEDIUM confidence
Chronic low-grade inflammation and oxidative stress in MASLD contribute to atrial structural and electrical remodeling, fostering an arrhythmogenic substrate.
Why this rating
Based on proposed hypotheses and animal models/cross-sectional studies cited.
Source
Metabolic-dysfunction associated steatotic liver disease and atrial fibrillation: A review of pathogenesis
Inderjeet S. Bharaj et al. · World Journal of Cardiology · 2025
DOI 10.4330/wjc.v17.i6.106147
narrative_reviewCited 14×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with a 19% increased risk of incident atrial fibrillation (AF), with risk escalating as liver disease severity (fibrosis/MASH) increases.Good
- Obesity and Obstructive Sleep Apnea (OSA) exacerbate the risk of AF in MASLD through hemodynamic changes, epicardial fat deposition, and sympathetic nervous system activation.Good
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