Hormonal
Interventions that delay or prevent the onset of type 2 diabetes in overweight/obese subjects with dysglycemia do not reduce the subsequent development or prevalence of diabetic retinopathy for up to 20 years.
If you have prediabetes or are at risk for type 2 diabetes, preventing or delaying the onset of diabetes through lifestyle changes or medication (like metformin) does not guarantee that you will avoid eye damage (retinopathy). Retinopathy can start during the prediabetic stage. Therefore, regular eye exams are crucial for people with prediabetes, regardless of whether they successfully prevent diabetes.
Interventions that delay or prevent the onset of type 2 diabetes in overweight/obese subjects with dysglycemia who are at risk for diabetes do not reduce the development of diabetic retinopathy for up to 20 years.
Why this rating
Large-scale, long-term (up to 20 years), randomized controlled trial (DPP/DPPOS) with rigorous fundus photography grading.
Source
The Effect of Interventions to Prevent Type 2 Diabetes on the Development of Diabetic Retinopathy: The DPP/DPPOS Experience
Neil H. White et al. · Diabetes Care · 2022
DOI 10.2337/dc21-2417
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