Hormonal
Intensive lifestyle interventions (ILI) involving caloric restriction and physical activity cause a significant increase in 25-hydroxyvitamin D [25(OH)D] and suppress parathyroid hormone (PTH) elevation during the period of maximal weight loss in adults with type 2 diabetes.
If you have type 2 diabetes and are losing weight through diet and exercise, expect your Vitamin D levels to rise and your Parathyroid Hormone (PTH) to decrease, especially in the first year. This is a normal and likely beneficial response to weight loss, though it may normalize over time. Monitor your bone health as weight loss can also lead to bone loss.
Intensive lifestyle intervention was associated with an increase in 25(OH)D and suppression of PTH elevation during the period of maximal weight loss.
Why this rating
Randomized controlled trial (Look AHEAD) with a subset analysis; however, the subset is small (n=123) and effects diminished by year 4.
Source
Weight loss lifestyle intervention and bone health hormonal markers in type 2 diabetes: analysis from look AHEAD study
Jiahuan Helen He et al. · Journal of the Endocrine Society · 2026
DOI 10.1210/jendso/bvag089
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