Adherence
Lifestyle interventions (caloric restriction and exercise) are the foundation of MASLD treatment but often fail to achieve sufficient or sustained weight loss, necessitating pharmaceutical intervention.
Start with lifestyle changes: eat less and move more. This is the foundation of treating fatty liver. However, be realistic: it is very hard to maintain these changes long-term, and many people struggle to lose enough weight. If lifestyle changes are not enough, talk to your doctor about adding medications like GLP-1RAs or SGLT2-is, which can help you achieve the weight loss needed to improve your liver health.
Major steps towards treating MASLD include a drastic change in the patient’s way of life, by adopting both caloric restriction and a regular exercise routine... Bariatric surgery can be implemented if the lifestyle approach is not enough. Unfortunately, failure is the case most of the time as the majority of patients prove to be unable to lose sufficient weight through diet and exercise alone or cannot maintain any targets they temporarily achieve.
Why this rating
Based on general clinical observation and cited guidelines, not a specific trial.
Source
Targeting Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Available and Future Pharmaceutical Options
Emmanouil Koullias et al. · Cureus · 2025
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