Hormonal
Women with type 2 diabetes face a disproportionately higher relative risk of major cardiovascular complications compared to men with type 2 diabetes, despite having lower absolute incidence rates in the general population.
If you are a woman with type 2 diabetes, your risk of heart disease and stroke is significantly higher relative to your non-diabetic peers than it is for men with diabetes. This means you cannot rely on general 'average' risk calculators. You need more aggressive management of blood pressure, lipids, and blood sugar than men might require for similar risk profiles, and you should advocate for this heightened level of care with your healthcare provider.
the relative risk of cardiovascular (CV) complications between individuals with and without T2D is higher in females than males... the relative risks for major CVD are up to 57% higher in women compared with men, even after controlling for common confounding variables such as age, obesity, smoking status, and blood pressure
Why this rating
Based on multiple large-scale meta-analyses and prospective cohort studies involving hundreds of thousands of participants.
Source
Sex and ethnic differences in the cardiovascular complications of type 2 diabetes
Jian L Yeo et al. · Therapeutic Advances in Endocrinology and Metabolism · 2021
DOI 10.1177/20420188211034297
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →