Hormonal

In individuals with type 2 diabetes and existing complications, a 5-day prolonged fasting-mimicking diet followed by a glucose load significantly reduces cellular resistance to dicarbonyl stress and increases oxidative stress markers, indicating heightened susceptibility to metabolic harm upon refeeding.

If you have Type 2 Diabetes with known complications (like kidney or nerve issues), extreme fasting followed by a large carbohydrate load may stress your cells more than it helps them. While fasting can improve insulin sensitivity in some, it appears to reduce your cells' ability to handle stress in this specific subgroup. Consult your doctor before attempting prolonged fasting, as your body may react with increased oxidative stress rather than metabolic improvement.