Hormonal
Once-weekly subcutaneous semaglutide 2.4 mg significantly reduces ad libitum energy intake, suppresses appetite, and improves control of eating in adults with obesity, leading to clinically meaningful weight loss, without evidence of delayed gastric emptying at steady state.
Take 2.4 mg of subcutaneous semaglutide once weekly. Start with the lowest dose (0.25 mg) and escalate every 4 weeks as directed to minimize side effects. Expect a significant reduction in hunger, food cravings, and overall calorie intake, leading to weight loss without needing to manually restrict calories.
In adults with obesity, once-weekly s.c. semaglutide 2.4 mg suppressed appetite, improved control of eating, and reduced food cravings, ad libitum energy intake and body weight versus placebo. There was no evidence of delayed gastric emptying at week 20, assessed indirectly via paracetamol absorption.
Why this rating
Randomized, double-blind, placebo-controlled trial with a robust sample size (n=72) and clear statistical significance for secondary endpoints.
Source
The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity
Martin Friedrichsen et al. · Diabetes Obesity and Metabolism · 2020
DOI 10.1111/dom.14280
Related findings · Hormonal
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- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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