Hormonal
Once-weekly semaglutide 2.4 mg significantly improves control of eating (specifically craving control and craving for savory foods) and sustains these improvements over 104 weeks, facilitating substantial weight loss in adults with overweight or obesity.
If you struggle with food cravings and hunger, especially when trying to lose weight, semaglutide 2.4 mg can help. It improves your ability to control what and how much you eat, particularly cravings for savory foods, and this effect lasts for at least two years. This helps you lose more weight and keep it off compared to lifestyle changes alone.
Scores significantly improved with semaglutide versus placebo for Craving Control and Craving for Savory domains at weeks 20, 52, and 104 (p < 0.01)... Improvements in craving domain scores were positively correlated with reductions in body weight from baseline to week 104 with semaglutide.
Why this rating
Phase 3, randomized, double-blind, placebo-controlled trial with a large sample size for the subgroup (n=174) and long duration (104 weeks).
Source
Two‐year effect of semaglutide 2.4 mg on control of eating in adults with overweight/obesity: <scp>STEP</scp> 5
Sean Wharton et al. · Obesity · 2023
DOI 10.1002/oby.23673
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →