Hormonal
Once-weekly subcutaneous semaglutide 2.4 mg combined with lifestyle intervention induces significant weight loss and improves cardiometabolic risk factors in adults with overweight/obesity and type 2 diabetes.
If you have type 2 diabetes and are overweight, adding once-weekly semaglutide 2.4 mg to your diet and exercise routine can lead to significantly more weight loss (about 10% of body weight on average) and better blood sugar control than diet and exercise alone. While you may experience temporary stomach issues, the long-term health benefits are substantial.
Semaglutide 2.4 mg, as adjunct to lifestyle intervention, was efficacious and well tolerated for weight management in adults with overweight or obesity and T2D, providing significantly greater weight loss vs placebo and semaglutide 1.0 mg at week 68.
Why this rating
Phase 3, randomized, double-blind, placebo-controlled trial with a large sample size (N=1,210) across multiple countries.
Source
Efficacy and Safety of Semaglutide 2.4 MG Once-Weekly in Adults With Overweight or Obesity and Type 2 Diabetes (STEP 2)
Melanie J. Davies et al. · Journal of the Endocrine Society · 2021
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