Hormonal
Once-weekly subcutaneous semaglutide 2.4 mg combined with lifestyle intervention induces a mean body weight loss of approximately 15% (14.9%) over 68 weeks in adults with overweight or obesity, significantly outperforming placebo.
If you have a BMI of 30 or higher (or 27 or higher with a weight-related health issue), adding once-weekly semaglutide 2.4 mg to your lifestyle changes can help you lose about 15% of your body weight over 16 months. This is significantly more than lifestyle changes alone. Be prepared for possible mild, temporary stomach issues, but the weight loss benefits are substantial and come with improvements in blood pressure and blood sugar.
In adults with overweight or obesity, once-weekly s.c. semaglutide 2.4 mg plus lifestyle intervention induced a mean weight loss of approximately 15% by week 68.
Why this rating
Phase 3, randomized, double-blind, placebo-controlled trial with a large sample size (N=1961) across 16 countries.
Source
Efficacy and Safety of Once-Weekly Subcutaneous Semaglutide 2.4 MG in Adults With Overweight or Obesity (STEP 1)
John Wilding et al. · Journal of the Endocrine Society · 2021
DOI 10.1210/jendso/bvab048.018
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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