Research
Hormonal
Discontinuation of semaglutide or tirzepatide leads to significant weight regain, indicating that these therapies require long-term use to maintain metabolic benefits.
If you stop taking semaglutide or tirzepatide, you will likely regain most of the weight you lost. These drugs treat obesity and diabetes as chronic conditions, meaning they are meant to be taken long-term to maintain the health benefits. Stopping them reverses the progress made.
StrongQualifiesHIGH confidence
participants regained about two-thirds of the weight they had lost within a year of stopping the medication
Why this rating
Supported by STEP 1 extension and STEP 4 trial data.
Source
Semaglutide and Tirzepatide: Revolutionary Therapies for Obesity and Type 2 Diabetes Mellitus Management
James P. Torres-Pirela · Ponce Health Sciences University Scientific Journal · 2025
narrative_review
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