Research

Macro partitioning

While weight loss is similar across macronutrient groups, specific diets produce distinct improvements in cardiovascular risk factors (e.g., LDL, HDL, Triglycerides).

If you have high cholesterol or cardiovascular risk, choose a diet that aligns with your specific biomarkers. Low-fat/high-carb diets tend to lower LDL (bad cholesterol) more effectively, while high-fat/low-carb diets may raise HDL (good cholesterol) more. Since weight loss is similar across all, use your lipid profile to guide your macronutrient choice.

StrongQualifiesHIGH confidence
The diets improved lipid-related risk factors and fasting insulin levels.
Frank M. Sacks et al. · New England Journal of Medicine · 2009

Why this rating

Same high-quality RCT data.

Source

Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and Carbohydrates

Frank M. Sacks et al. · New England Journal of Medicine · 2009

rct · n=811Cited 1,953×
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