Mixed
Sustained weight loss (≥10%) achieved through a multidisciplinary lifestyle intervention (low-energy Mediterranean-style diet and increased physical activity) significantly reduces circulating vascular inflammatory markers (IL-6, IL-18, CRP) and increases anti-inflammatory adiponectin in obese women.
To reduce inflammation and cardiovascular risk, obese women should aim for a 10% or greater weight loss using a Mediterranean-style diet (high in complex carbs, fiber, and monounsaturated fats; low in saturated fat) combined with increased physical activity (aiming for ~175 minutes/week). This should be supported by regular professional guidance and self-monitoring to ensure long-term adherence.
In this study, a multidisciplinary program aimed to reduce body weight in obese women through lifestyle changes was associated with a reduction in markers of vascular inflammation and insulin resistance.
Why this rating
Randomized controlled trial with a 2-year duration and clear statistical significance, though limited to premenopausal women without comorbidities.
Source
Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women
Katherine Esposito et al. · JAMA · 2003
DOI 10.1001/jama.289.14.1799
Related findings · Mixed
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