Research

Macro partitioning

Low-carbohydrate diets improve favorable cardiovascular risk markers (Triglycerides and HDL) compared to low-fat diets, but worsen LDL cholesterol levels.

If you switch to a low-carb diet, expect your HDL (good cholesterol) to go up and Triglycerides to go down, which is good. However, your LDL (bad cholesterol) may rise compared to a low-fat diet. You should monitor your full lipid panel and discuss these trade-offs with your doctor, as the net cardiovascular benefit is unclear.

ModerateQualifiesMEDIUM confidence
Triglyceride and high-density lipoprotein cholesterol values changed more favorably in individuals assigned to low-carbohydrate diets... but total cholesterol and low-density lipoprotein cholesterol values changed more favorably in individuals assigned to low-fat diets
Alain Nordmann et al. · Archives of Internal Medicine · 2006

Why this rating

Meta-analysis of RCTs, but small sample size and moderate quality.

Source

Effects of Low-Carbohydrate vs Low-Fat Diets on Weight Loss and Cardiovascular Risk Factors

Alain Nordmann et al. · Archives of Internal Medicine · 2006

DOI 10.1001/archinte.166.3.285

Meta-analysis · 5 studiesCited 975×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

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