Research
Hormonal
GLP-1R agonists improve glycaemic control in patients with type 2 diabetes by reducing HbA1c and increasing the proportion of patients achieving target HbA1c levels, without causing significant hypoglycemia.
For people with type 2 diabetes, GLP-1R agonists are effective at lowering blood sugar (HbA1c) and helping more people reach their target levels, without the risk of dangerous low blood sugar (hypoglycemia) associated with other diabetes medications.
WeakSupportsHIGH confidence
In patients with type 2 diabetes, the highest doses of GLP-1R agonists reduced HbA1c percentage compared with placebo, oral antidiabetic drugs, or insulin... The proportion of participants who achieved the haemoglobin target (HbA1c <7%) was higher in the GLP-1R agonists group than in controls.
Why this rating
Meta-analysis of 25 RCTs.
Source
Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials
Tina Vilsbøll et al. · BMJ · 2012
DOI 10.1136/bmj.d7771
Meta-analysis · 25 studiesCited 953×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Treatment with glucagon-like peptide-1 receptor (GLP-1R) agonists (exenatide or liraglutide) at clinically relevant doses for at least 20 weeks results in significant weight loss in overweight or obese patients, regardless of type 2 diabetes status.Weak
- GLP-1R agonists improve cardiovascular risk factors by reducing systolic and diastolic blood pressure and total cholesterol concentrations.Weak
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
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- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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