Hormonal
Once-daily subcutaneous liraglutide (2.4–3.0 mg) combined with a 500 kcal/day caloric deficit and exercise counseling sustains significant weight loss (7.8 kg) and improves cardiovascular risk factors (blood pressure, lipids, prediabetes) over a 2-year period in obese non-diabetic adults.
If you are obese and have not been able to lose weight through diet and exercise alone, adding once-daily liraglutide (2.4-3.0 mg) to a moderate caloric deficit (500 kcal/day) and exercise can help you sustain significant weight loss (around 8 kg) and improve your blood pressure and cholesterol over two years. Expect some initial nausea, which usually subsides, and be prepared for daily injections.
Liraglutide is well tolerated, sustains weight loss over 2 years and improves cardiovascular risk factors.
Why this rating
Randomized, double-blind, placebo-controlled trial with a 2-year extension, large sample size (n=564), and rigorous statistical analysis.
Source
Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
on behalf of the NN8022-1807 Investigators et al. · International Journal of Obesity · 2011
DOI 10.1038/ijo.2011.158
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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