Research
Hormonal
Intermittent fasting significantly increases adiponectin and decreases leptin levels, which may contribute to improved insulin sensitivity independent of significant fat mass loss.
Fasting may improve your metabolic health markers (like adiponectin) even if the scale doesn't move much, suggesting benefits beyond just weight loss.
GoodSupportsHIGH confidence
Although there was no significant change in fat mass after an IFD, an IFD was associated with an increase in adiponectin level... and a decrease in leptin level
Why this rating
Meta-analysis data, though fat mass change was not significant.
Source
The Effectiveness of Intermittent Fasting to Reduce Body Mass Index and Glucose Metabolism: A Systematic Review and Meta-Analysis
Yongin Cho et al. · Journal of Clinical Medicine · 2019
DOI 10.3390/jcm8101645
Meta-analysis · 12 studiesCited 200×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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