Hormonal
Intermittent energy restriction (IER) significantly reduces fasting insulin levels compared to continuous energy restriction (CER), although the clinical relevance is uncertain.
IER may offer a slight advantage in lowering fasting insulin compared to daily restriction, which could be beneficial for metabolic health. However, since weight loss is the same, do not expect dramatic changes in body composition solely from this hormonal shift.
A slight reduction in fasting insulin concentrations was evident with IER regimens (WMD − 0.89 µU/mL; 95% CI − 1.56 to − 0.22; p = 0.009), but the clinical relevance of this result is uncertain.
Why this rating
Meta-analysis of 11 RCTs, robust sensitivity analysis, but clinical significance is ambiguous.
Source
Intermittent versus continuous energy restriction on weight loss and cardiometabolic outcomes: a systematic review and meta-analysis of randomized controlled trials
Iolanda Cioffi et al. · Journal of Translational Medicine · 2018
DOI 10.1186/s12967-018-1748-4
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →