Research
Hormonal
In obese men with metabolic syndrome, weight loss decreases HDL apoA-I production and catabolism by equal amounts, resulting in no net change in plasma HDL cholesterol concentrations.
Don't be discouraged if your HDL numbers don't jump after losing weight. This study shows that weight loss can improve how your body handles cholesterol (LDL) without necessarily raising HDL levels, which is still beneficial for heart health.
GoodRefutesHIGH confidence
it also decreased both the catabolic (-13%) and production (-13%) rates of HDL apoA-I (P < 0.05), thereby not altering plasma HDL apoA-I or HDL cholesterol concentrations.
Why this rating
Controlled trial with precise kinetic modeling.
Source
Effect of Weight Loss on LDL and HDL Kinetics in the Metabolic Syndrome
T Ng et al. · Diabetes Care · 2007
DOI 10.2337/dc07-0768
rct · n=35Cited 101×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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