Research
Hormonal
Alternate-Day Fasting (ADF) improves insulin sensitivity (HOMA-IR) more than Continuous Energy Restriction (CER).
If you are using Alternate-Day Fasting, you may see improvements in insulin sensitivity that are not seen with standard calorie restriction. This is a potential metabolic benefit of ADF.
GoodSupportsMEDIUM confidence
whereas ADF improved HOMA-IR more.
Why this rating
Based on subgroup analysis of RCTs within a meta-analysis.
Source
Effects of Intermittent Energy Restriction Compared with Those of Continuous Energy Restriction on Body Composition and Cardiometabolic Risk Markers – A Systematic Review and Meta-Analysis of Randomized Controlled Trials in Adults
Maite M. Schroor et al. · Advances in Nutrition · 2023
DOI 10.1016/j.advnut.2023.10.003
Meta-analysis · 28 studiesCited 50×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Intermittent energy restriction (IER) diets (time-restricted eating, alternate-day fasting, and 5:2 diet) do not produce superior improvements in body weight, fat mass, or cardiometabolic risk markers compared to continuous energy restriction (CER) when total energy intake is matched.Strong
- Time-Restricted Eating (TRE) results in greater reductions in body weight, fat mass, and fat-free mass compared to Continuous Energy Restriction (CER).Good
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