Hormonal
Moderate weight loss (7-10% of initial body weight) significantly reduces ectopic lipid content in the liver, pancreas, and visceral adipose tissue, with liver lipid reduction being the strongest independent predictor of improved insulin resistance.
Losing just 7-10% of your body weight through a moderate caloric deficit (500 kcal/day below maintenance) can drastically reduce fat stored in your liver and pancreas. This specific reduction in ectopic fat is more critical for fixing insulin resistance than just losing belly fat. Focus on sustainable, moderate weight loss rather than extreme diets to see significant metabolic health improvements.
After weight loss, percentage of subjects with liver steatosis decreased from 75 to 12.5%. Insulin resistance improvement was predicted by changes in liver lipid content independently of changes in visceral fat, pancreas lipid content, systemic inflammation, leptin and gender.
Why this rating
Randomized controlled trial design with objective MRI measurements and statistical controls, though sample size is small (n=24).
Source
Effect of moderate weight loss on hepatic, pancreatic and visceral lipids in obese subjects
Andrea P. Rossi et al. · Nutrition and Diabetes · 2012
DOI 10.1038/nutd.2012.5
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