Research
Hormonal
Caloric restriction improves insulin sensitivity and reduces fasting insulin, but has a minor or non-significant impact on fasting glucose levels in balanced groups.
Caloric restriction lowers insulin levels, which improves insulin sensitivity. However, it may not significantly lower fasting blood glucose unless the study groups were balanced at baseline.
GoodQualifiesMEDIUM confidence
All showed a reduction of fasting insulin after CR in comparison to controls... A reduction was seen in fasting glucose by −1.31 mg/dL... with an effect only for balanced group
Why this rating
Meta-analysis of 5 RCTs for insulin, 3 for glucose, with some heterogeneity.
Source
Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Silvia Caristia et al. · Nutrients · 2020
DOI 10.3390/nu12082290
Meta-analysis · 8 studiesCited 41×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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