Hormonal
Lower adipose NPR-C mRNA expression and higher NPR-A mRNA expression after weight loss predict better long-term weight maintenance and improved insulin sensitivity, independent of the weight maintenance intervention.
Your body's molecular response to weight loss (specifically the ANP system in fat tissue) may predict how well you maintain your weight and insulin sensitivity long-term. While you cannot change this directly, it suggests that personalized monitoring might be needed for those with less favorable molecular profiles.
Lower adipose NPR-C and higher NPR-A mRNA expression after weight loss predicted smaller regain of weight... and longer improvement of HOMA-IR...
Why this rating
Predictive analysis within an RCT; strong correlation but observational nature of the prediction.
Source
Weight loss-induced improvement of body weight and insulin sensitivity is not amplified by a subsequent 12-month weight maintenance intervention but is predicted by adaption of adipose atrial natriuretic peptide system: 48-month results of a randomized controlled trial
Linna Li et al. · BMC Medicine · 2022
DOI 10.1186/s12916-022-02435-9
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