Hormonal
Lorcaserin (10 mg twice daily) produces significant weight loss and improves cardiometabolic risk factors in obese adults by selectively activating 5-HT2C receptors to reduce energy intake without increasing energy expenditure.
Take 10mg of Lorcaserin twice daily, ideally before breakfast and dinner, while following a lifestyle program that creates a moderate caloric deficit. This medication works by reducing your appetite through specific brain receptors, leading to significant weight loss and improved metabolic markers like blood pressure and cholesterol without increasing your energy expenditure.
Lorcaserin acts to alter energy balance through a reduction in energy intake and without an increase in energy expenditure and achieved the U.S. Food and Drug Administration guidelines for weight loss efficacy.
Why this rating
Supported by Phase II and III randomized, double-blind, placebo-controlled trials with large sample sizes (n=469 and n=3,182).
Source
Lorcaserin for the treatment of obesity
Leanne M. Redman et al. · Drugs of today · 2010
DOI 10.1358/dot.2010.46.12.1556433
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