Mixed
An energy-reduced anti-inflammatory diet significantly improves hepatic status indices (NAFLD-FLS, FLI, FIB-4) and reduces inflammatory biomarkers in younger adults with obesity compared to a standard isocaloric diet.
To improve liver health and reduce inflammation, focus on an energy-reduced diet rich in anti-inflammatory foods like vegetables, fruits, whole grains, fish, and olive oil. This approach was shown to significantly improve liver fat scores and reduce inflammatory markers in adults with obesity over 6 months, outperforming a standard weight loss diet in some inflammatory markers.
Energy-restricted anti-inflammatory diet resulted in significant weight loss (− 7.1%, p < 0.001), in reducing the visceral adiposity (− 22.3%, p < 0.001), metabolic (HOMA-IR, − 15.5%; total cholesterol, − 5.3%; LDL-C, − 4.6%; triglycerides, − 12.2%), and inflammatory biomarkers (hs-CRP, − 29.5%; IL-6, − 18.2%; TNF-α, − 34.2%), with significant improvement of liver parameters (NAFLD-FLS, − 143.4%; FLI, − 14.3%; FIB-4, − 2.5%).
Why this rating
Randomized controlled trial with a reasonable sample size (n=81) and clear statistical significance, though limited to a specific demographic (younger adults with obesity).
Source
Metabolic and Hepatic Effects of Energy‐Reduced Anti‐Inflammatory Diet in Younger Adults with Obesity
Gordana Kenđel Jovanović et al. · Canadian Journal of Gastroenterology and Hepatology · 2021
DOI 10.1155/2021/6649142
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