Research
Hormonal
Combining sibutramine (10-15 mg/day) with a low-calorie diet using meal replacements and behavioral modification significantly improves both weight loss and long-term weight maintenance compared to diet and behavioral modification alone.
To lose weight and keep it off, combine a prescription medication (sibutramine) with a structured low-calorie diet that includes meal replacement shakes and behavioral counseling. This combination was significantly more effective than diet and counseling alone in maintaining weight loss over 12 months.
GoodSupportsHIGH confidence
Sibutramine plus LCD with meal replacements and behavior modification is a safe and effective strategy for achieving and sustaining weight loss in obese patients.
Why this rating
Randomized, placebo-controlled, multi-center trial with a large sample size (n=148) and long duration (12 months).
Source
Sibutramine Plus Meal Replacement Therapy for Body Weight Loss and Maintenance in Obese Patients
James L. Early et al. · Obesity · 2007
DOI 10.1038/oby.2007.175
rct · n=148Cited 21×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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