Adherence
4:3 intermittent fasting (80% energy restriction on 3 nonconsecutive days/week) produces modestly greater weight loss than matched daily caloric restriction over 12 months when both are delivered within a high-intensity, comprehensive behavioral weight loss program.
If you struggle with daily calorie counting, try 4:3 intermittent fasting: restrict calories by 80% on 3 nonconsecutive days a week and eat normally on the other 4. This approach led to slightly better weight loss than daily restriction in a 12-month study, likely because it is easier to stick to. Combine this with regular exercise and behavioral support for best results.
Compared with DCR, 4:3 IMF resulted in modestly greater weight loss among adults with overweight or obesity enrolled in a 12-month, high-intensity, comprehensive behavioral weight loss program.
Why this rating
Randomized clinical trial with intention-to-treat analysis, matched energy deficits, and comprehensive behavioral support.
Source
The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months
Victoria A. Catenacci et al. · Annals of Internal Medicine · 2025
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