Hormonal
Sibutramine (15 mg daily) combined with lifestyle interventions produces significant weight reduction and improves metabolic risk factors in obese women with polycystic ovary syndrome (PCOS).
If you have PCOS and are overweight, sibutramine (15mg daily) combined with standard diet and exercise advice can help you lose significantly more weight than lifestyle changes alone. It also improves metabolic markers like triglycerides. Discuss this option with your doctor, especially since other common PCOS drugs like Metformin are not primarily effective for weight loss.
Sibutramine, when combined with lifestyle interventions, can lead to significant weight reduction in obese women with PCOS. In addition, it seems to have positive effects on metabolic and cardiovascular risk factors.
Why this rating
Randomized, double-blind, placebo-controlled trial, though with a small sample size (34 completers).
Source
Weight Loss With a Low-Carbohydrate, Mediterranean, or Low-Fat Diet
Iris Shai et al. · Obstetrical & Gynecological Survey · 2008
DOI 10.1097/01.ogx.0000334740.32446.f3
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