Hormonal
The effect of Tirzepatide on Fat-Free Mass (FFM) is inconclusive and potentially adverse, with some studies showing greater FFM loss compared to other anti-obesity drugs, particularly at higher doses.
While Tirzepatide is excellent for fat loss, patients should be aware that it may also cause a loss of lean muscle mass, potentially more than other similar drugs. To mitigate this, combining TZP treatment with resistance training and adequate protein intake is crucial, although clinical data on optimizing FFM preservation with TZP is currently lacking.
the effect of TZP on fat-free mass (FFM) is still uncertain because the findings remain inconclusive... TZP seems to determine a higher reduction/deterioration in FFM compared to that of other medications (dulaglutide and semaglutide) by nearly 0.8–2 kg, which appears to occur at the highest dose of TZP (i.e., 15 mg)
Why this rating
Findings are inconsistent across small samples and different measurement methods (BIA vs DXA).
Source
De las ideas a los proyectos : la creatividad como pilar básico del emprendimiento
Mariona Masgrau Juanola et al. · Aula de innovación educativa · 2012
DOI 10.3390/diseases12090204
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