Hormonal
Flexible time-restricted eating combined with aerobic exercise improves insulin resistance (HOMA-IR) and insulin levels more effectively than either intervention alone.
To improve your insulin sensitivity, combining an 8-hour eating window with regular moderate aerobic exercise is more effective than doing either one alone. This approach helps lower insulin levels and improve insulin resistance markers more significantly than diet or exercise in isolation.
the combined group (flexTRE+EX) exhibited a larger reduction compared to the other two intervention groups (flexTRE+EX vs. flexTRE: −2.98 mU/L [−5.06 to −0.89]; P < 0.001; flexTRE+EX vs. EX: −2.84 mU/L [−5.25 to −0.42]; P = 0.003) at post-intervention... Similarly, group-by-time interaction effects were also observed in the homeostatic model assessment of insulin resistance (HOMA-IR)... the combined group showed a larger reduction compared to the other two intervention groups
Why this rating
RCT with clear statistical significance for insulin and HOMA-IR improvements in the combined group.
Source
Flexible time-restricted eating combined with exercise in a free-living setting for middle-aged women with overweight/obesity: a randomized controlled trial
Zi-Han Dai et al. · Nature Communications · 2025
DOI 10.1038/s41467-025-65678-z
More from this paper
- Combining flexible time-restricted eating (8-hour window) with aerobic exercise yields significantly greater fat mass reduction than either intervention alone in middle-aged women with overweight/obesity.Good
- Flexible time-restricted eating leads to a spontaneous reduction in total energy intake without altering macronutrient composition.Good
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