Research
Hormonal
Once-weekly semaglutide improves cardiometabolic markers including HbA1c, fasting plasma glucose, blood pressure, and lipid profiles in overweight/obese patients, independent of or alongside weight loss.
Beyond weight loss, semaglutide helps improve blood sugar control (HbA1c), blood pressure, and lipid profiles in overweight/obese individuals, offering broader cardiovascular protection.
StrongSupportsHIGH confidence
Semaglutide also reduced BMI and WC, and benefited glycaemic, blood pressure and triglyceride regulation.
Why this rating
Meta-analysis of 9 RCTs.
Source
Effects of once-weekly semaglutide in obese/overweight patients: A systematic review and meta-analysis
Mengjun Wang et al. · Research Square · 2022
DOI 10.21203/rs.3.rs-2346356/v1
Meta-analysis · 9 studies
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Once-weekly subcutaneous semaglutide (up to 2.4 mg) significantly reduces body weight, BMI, and waist circumference in adults with obesity or overweight compared to placebo, with effects demonstrating a dose-response relationship.Strong
- Semaglutide treatment is associated with a significantly higher incidence of gastrointestinal adverse events (nausea, diarrhea, vomiting, constipation) compared to placebo, though these are mostly mild to moderate.Strong
Related findings · Hormonal
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- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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